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Unable to configure office 365 Mailbox in Outlook

1.      How many users are affected?
2.      Check if the autodiscover records are updated for the domain.
3.      Check the Cname records “autodiscover.domain.com” should point to “autodiscover.outlook.com”If these records are not updated, please update these records in domain DNS file.
4.      Check if the profile can be configured on a non-domain and domain joined machine.

If the profile is not getting configure please share the details of the below mentioned tests.
Autodiscover test.

Please open the below link and go to office 365.
Select: Microsoft Office Outlook Connectivity Tests
Please share the results for both the test. 
Outlook Connectivity
Outlook autodiscover 
Note: Please use the end user’s credentials only.

Try to Disable MAPI for the user. Run PowerShell as admin.

Set-ExecutionPolicy RemoteSigned
 $cred = Get-Credential 
 $ExchangeSession = New-PSSession -ConfigurationName Microsoft.Exchange -ConnectionUri "https://outlook.office365.com/powershell-liveid/" -Credential $credential -Authentication "Basic" -AllowRedirection
 Import-PSSession $ExchangeSession

Disable the MAPI connectivity.
Set-CASMailbox -Identity aliciap@ppmechanical.com -MAPIEnabled $false

Enable the MAPI connectivity.
Set-CASMailbox -Identity aliciap@ppmechanical.com -MAPIEnabled $true

Try to configure the profile now.

Test the Mapi connectivity.
Connect office 365 to PowerShell
Start-Transcript
Set-ExecutionPolicy RemoteSigned
$cred = Get-Credential 
$ExchangeSession = New-PSSession -ConfigurationName Microsoft.Exchange -ConnectionUri "https://outlook.office365.com/powershell-liveid/" -Credential $credential -Authentication "Basic" -AllowRedirection
Import-PSSession $ExchangeSession
Test-MapiConnectivity
Stop –Transcript

If we are not able to configure the profile on a domain joined machine then the possible cause can be the SCP lookup.

If you have local Active Directory structure, and the computers are joined to a local AD domain, when Outlook client starts the autodiscover process, it will first try to find the information used for autodiscover by using Service Connection Point (SCP), instead of DNS lookup. Actually, SCP is always the first thing that autodiscover checks for, and if it isn't found then it moves on to a DNS check.
Therefore, Outlook clients may directly connect to SCP instead of through DNS to use autodiscover service. You can bypass the SCP check by modifying the registry key:

1. Click Start, and then click Run.
2. In the Run dialog box, type regedit, and then click OK.
3. In Registry Editor, go to the following registry key: HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Outlook\AutoDiscover]
4. Add the following autodiscover entries: "ExcludeScpLookup"=dword:00000001


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